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Dr. Castellanos set of medical credentials include Board Certified by the American Academy of Medical Specialties in Physical Medicine & Rehabilitation. Interventional Pain Management. Assistant Professor of Neurological Science at Florida International University. Dr. Castellanos" extensive training and education were attained from top-ranking universities including University of South Florida College of Medicine - 2002 State University of New York -Health Science Center at Stony Brook - 2001 Cornell University Medical College NY Hospital - 1998 Institute of Superior Medical Science of Havana - 1987 In addition, Dr. Castellanos has developed several highly specialized products, tools and even patented technique (called Prometheus ®) to help him be at the forefront in his medical practice
To evaluate the short-term safety and effectiveness of amniotic membrane/umbilical cord particulate (AMUC) in managing pain in patients with various severities of knee osteoarthritis (OA). Design. Single-center, prospective, investigator-initiated pilot study. Setting. Private practice. Subjects. A total of 20 knee OA patients aged 18 years were enrolled with pain >40 mm, as determined by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)–A. Methods. Patients received an ultrasound-guided, intra-articular injection of 50 mg of AMUC particulate reconstituted in 2 mL of preservative-free saline. All patients were then monitored at six weeks, 12 weeks, and 24 weeks postinjection. Patients who did not show >30% reduction in pain received a second injection of AMUC at six weeks. WOMAC, Patient Global Assessment, medication usage, and magnetic resonance imaging (MRI) were assessed. Results. Knee OA pain significantly decreased from 74.3 6 17.2 at baseline to 45.0 6 25.4 at six weeks (P < 0.01), 35.4 6 26.6 at 12 weeks (P < 0.001), and 37.4 6 26.7 at 24 weeks (P < 0.001). This pain reduction was associated with a significant improvement in physical function (WOMAC-C) at all time points (P < 0.05) and stiffness (WOMAC-B) at 12 weeks (P ¼ 0.01). Eleven patients received a second injection, which was significantly correlated with body mass index >30 kg/m2 (P ¼ 0.025). MRI evaluation of the overall population revealed an improvement in the severity of bone marrow lesions in seven patients. No adverse events were observed. Conclusions. AMUC particulate injection relieved pain and improved physical function in patients with symptomatic knee OA.